Mesenchymal Stem / Stromal Cells
Scalable, xeno-free MSC manufacturing on microcarriers or aggregates, from flasks to 80 L, with extracellular-vesicle potential built in.
MSCs and MSC-derived EVs are in numerous clinical trials, driving demand for billions to trillions of cells per lot. The Vertical-Wheel® low-shear environment protects these shear-sensitive cells while distributing gas and nutrients uniformly.
Uniform low-shear mixing protects hMSC viability and phenotype while keeping microcarriers or aggregates suspended.
Even microcarrier suspension, including customizable and dissolvable options that improve harvest and direct visualization.
Xeno-free fed-batch processes lift final cell yields and EV cargo across 0.1 L to 50 L scales.
What You Can Build.
Workflows our customers and collaborators run on the Vertical-Wheel® platform, every one backed by published data or a protocol below.
- BM-MSC expansion
- Cord-blood MSC
- Adipose-derived MSC
- Microcarrier culture
- Fed-batch processes
- MSC-derived EVs
A xeno-free hMSC process maintained critical quality attributes across 0.1 L, 3 L, 15 L and 50 L Vertical-Wheel® scales.
The Evidence for MSCs.
Application notes, protocols and peer-reviewed data with tangible results in Vertical-Wheel® bioreactors, leading with the studies that show real numbers.
Ready to Scale Your MSCs Process?
Talk to an application scientist about a Vertical-Wheel® path tuned to your cell type and timeline.