PBS Biotech
Exosomes & EVs

Exosomes & Extracellular Vesicles

Boost EV yield and cargo quality with 3D dynamic culture, a scalable route to therapeutic vesicle and exosome production.
↑ yield
vs planar culture
3D
dynamic culture
MSC·NK·organoid
EV sources
Why Vertical-Wheel

Built For This Cell Type.

Higher EV yield

3D aggregate and microcarrier culture in dynamic conditions upregulates EV secretion relative to static planar culture.

Better cargo

Bioreactor conditions enhance the therapeutic cargo and proteomic profile of secreted vesicles.

Scalable production

A clear path from bench development to large-scale therapeutic EV manufacturing.

Applications

  • MSC-derived EVs
  • NK-derived EVs
  • Organoid-derived exosomes
  • EV manufacturing
  • Drug-delivery vesicles

Systems for This Cell Type

Each system carries the note explaining why it suits this cell type.

  • PBS-MiniEV process development
  • PBS-3Scaled EV production
  • PBS-15Clinical EV batches
  • PBS-80Commercial EV supply
↑ EV

Upscaling hMSC production in a Vertical-Wheel® bioreactor enhanced extracellular-vesicle secretion and improved cargo profile versus planar culture.

Bioactive Materials, 2023
Evidence

The Data Behind It.

All resources

No documents are tagged for this cell type yet.

Talk Through Your Process.

Our scientists work on these processes daily. Bring us your cell type, your scale and your constraints.