Stem-Cell-Derived Islets
Built For This Cell Type.
Homogeneous low-shear mixing keeps aggregate size distributions narrow across a multi-week differentiation, the critical quality attribute for islet identity and function.
A five-fold volume increase delivered twelve times more islets with no quality compromise, so a process developed small carries its economics upward.
Islets manufactured this way were glucose-responsive in vitro and reversed diabetes in every transplanted animal.
Applications
- SC-islets (diabetes)
- Directed differentiation
- Aggregate culture
- hiPSC / PSC expansion
- Disease modeling
Systems for This Cell Type
Each system carries the note explaining why it suits this cell type.
- PBS-MiniIslet differentiation development
- PBS-MiniPROParallel differentiation screening
- PBS-3Scaled differentiation (GMP runs)
- PBS-15Clinical-scale islet batches
- PBS-80Differentiation demonstrated to 50 L
A single 0.5 L Vertical-Wheel® batch produced roughly 183,000 islet-equivalents (IEQ) of glucose-responsive SC-islets, enough by published dosing to treat a ~34 lb patient, and the SC-islets reversed diabetes in all fifteen transplanted mice.
The Data Behind It.
No documents are tagged for this cell type yet.
Talk Through Your Process.
Our scientists work on these processes daily. Bring us your cell type, your scale and your constraints.