An Innovative, Scalable, Single-Use Bioreactor Platform

This poster presents the application of Vertical-Wheel bioreactor technology for scalable cell therapy manufacturing processes. Multiple case studies demonstrate expansion and differentiation of human induced pluripotent stem cells, embryonic stem cells, mesenchymal stem cells, and organoid cultures across increasing scales. The work highlights the ability of Vertical-Wheel systems to maintain aggregate size uniformity, support scalable fed-batch microcarrier cultures, preserve key cell quality attributes, and enable consistent process performance between development and production scales. Data from multiple collaborators show successful scale-up from small research volumes through pilot and manufacturing scales while maintaining cell growth, differentiation efficiency, and critical quality attributes. The poster emphasizes scalability, process robustness, and suitability for allogeneic cell therapy manufacturing.